Léger L, Aalders J, Heymans N, Van Acker-Verberckt K, De Bleeckere L, Coucke P, Menten B, Bauce B, Vitiello L, Rampazzo A, Calore M, van Hengel J. Generation of a human induced pluripotent stem cell line UGENTi002-A from an arrhythmogenic cardiomyopathy patient carrying the c.817C>T DSP heterozygous variant and isogenic control using CRISPR/Cas9 editing. Stem Cell Res. 2024 [doi] [PubMed]
Vilaça A, Jesus C, Lino M, Hayman D, Emanueli C, Terracciano CM, Fernandes H, de Windt LJ, Ferreira L. Extracellular vesicle transfer of lncRNA H19 splice variants to cardiac cells. Mol Ther Nucleic Acids. 2024 [doi] [PubMed]
Beslika E, Leite-Moreira A, De Windt LJ, da Costa Martins PA. Large animal models of pressure overload-induced cardiac left ventricular hypertrophy to study remodelling of the human heart with aortic stenosis. Cardiovasc Res. 2024 [doi] [PubMed]
Salavati A, van der Wilt CN, Calore M, van Es R, Rampazzo A, van der Harst P, van Steenbeek FG, van Tintelen JP, Harakalova M, Te Riele ASJM. Artificial Intelligence Advancements in Cardiomyopathies: Implications for Diagnosis and Management of Arrhythmogenic Cardiomyopathy. Curr Heart Fail Rep. 2024 [doi] [PubMed]
Vencato S, Romanato C, Rampazzo A, Calore M. Animal Models and Molecular Pathogenesis of Arrhythmogenic Cardiomyopathy Associated with Pathogenic Variants in Intercalated Disc Genes. Int J Mol Sci. 2024 [doi] [PubMed]
Spanò G, Pehlivanoğlu S, De Windt LJ. Heracles and the Lernaean Hydra: uncovering new layers of transcriptome regulation. Cardiovasc Res. 2024 [doi] [PubMed]
Cerqueira R, Moreira-Costa L, Beslika E, Leite-Moreira A, Silva J, da Costa Martins PA, Leite-Moreira A, Lourenço A, Mendes-Ferreira P. A Minimally Invasive Model of Aortic Stenosis in Swine. J Vis Exp. 2023 [doi] [PubMed]
Juni RP, Kocken JMM, Abreu RC, Ottaviani L, Davalan T, Duygu B, Poels EM, Vasilevich A, Hegenbarth JC, Appari M, Bitsch N, Olieslagers S, Schrijvers DM, Stoll M, Heineke J, de Boer J, de Windt LJ, da Costa Martins PA. MicroRNA-216a is essential for cardiac angiogenesis. Mol Ther. 2023 [doi] [PubMed]
Soragni C, Vergroesen T, Hettema N, Rabussier G, Lanz HL, Trietsch SJ, de Windt LJ, Ng CP. Quantify permeability using on-a-chip models in high-throughput applications. STAR Protoc. 2023 [doi] [PubMed]
de Boer M, Te Lintel Hekkert M, Chang J, van Thiel BS, Martens L, Bos MM, de Kleijnen MGJ, Ridwan Y, Octavia Y, van Deel ED, Blonden LA, Brandt RMC, Barnhoorn S, Bautista-Niño PK, Krabbendam-Peters I, Wolswinkel R, Arshi B, Ghanbari M, Kupatt C, de Windt LJ, Danser AHJ, van der Pluijm I, Remme CA, Stoll M, Pothof J, Roks AJM, Kavousi M, Essers J, van der Velden J, Hoeijmakers JHJ, Duncker DJ. DNA repair in cardiomyocytes is critical for maintaining cardiac function in mice. Aging Cell. 2023 [doi] [PubMed]
Vilaça A, de Windt LJ, Fernandes H, Ferreira L. Strategies and challenges for non-viral delivery of non-coding RNAs to the heart. Trends Mol Med. 2023 [doi] [PubMed]
Rabussier G, Bünter I, Bouwhuis J, Soragni C, van Zijp T, Ng CP, Domansky K, de Windt LJ, Vulto P, Murdoch CE, Bircsak KM, Lanz HL. Healthy and diseased placental barrier on-a-chip models suitable for standardized studies. Acta Biomater. 2023 [doi] [PubMed]
Fernandes H, Zonnari A, Abreu R, Aday S, Barão M, Albino I, Lino M, Branco A, Seabra C, Barata T, Leal EC, Tralhão JG, Gonçalves L, de Jong A, Peters HAB, de Vries MR, da Costa Martins P, Quax PHA, Ferreira L. Extracellular vesicles enriched with an endothelial cell pro-survival microRNA affects skin tissue regeneration. Mol Ther Nucleic Acids. 2022 [doi] [PubMed]
Ottaviani L, Juni RP, de Abreu RC, Sansonetti M, Sampaio-Pinto V, Halkein J, Hegenbarth JC, Ring N, Knoops K, Kocken JMM, Jesus C, Ernault AC, El Azzouzi H, Rühle F, Olieslagers S, Fernandes H, Ferreira L, Braga L, Stoll M, Nascimento DS, de Windt LJ, da Costa Martins PA. Intercellular transfer of miR-200c-3p impairs the angiogenic capacity of cardiac endothelial cells. Mol Ther. 2022 [doi] [PubMed]
Silva J, da Costa Martins PA. Non-Coding RNAs in the Therapeutic Landscape of Pathological Cardiac Hypertrophy. Cells. 2022 [doi] [PubMed]
Videira RF, Koop AMC, Ottaviani L, Poels EM, Kocken JMM, Dos Remedios C, Mendes-Ferreira P, Van De Kolk KW, Du Marchie Sarvaas GJ, Lourenço A, Llucià-Valldeperas A, Nascimento DA, De Windt LJ, De Man FS, Falcão-Pires I, Berger RMF, da Costa Martins PA. The adult heart requires baseline expression of the transcription factor Hand2 to withstand right ventricular pressure overload. Cardiovasc Res. 2022 [doi] [PubMed]
De Windt LJ. Grand challenges in molecular cardiology. Front Mol Med. 2022 [doi] [PubMed]
Soragni C, Rabussier G, Lanz HL, Bircsak KM, de Windt LJ, Trietsch SJ, Murdoch CE, Ng CP. A versatile multiplexed assay to quantify intracellular ROS and cell viability in 3D on-a-chip models. Redox Biol. 2022 [doi] [PubMed]
Mangraviti N, De Windt LJ. Long Non-Coding RNAs in Cardiac Hypertrophy. Front Mol Med. 2022 [doi] [PubMed]
Hegenbarth JC, Lezzoche G, De Windt LJ, Stoll M. Perspectives on Bulk-Tissue RNA Sequencing and Single-Cell RNA Sequencing for Cardiac Transcriptomics. Front Mol Med. 2022 [doi] [PubMed]
Sansonetti M, De Windt LJ. Non-coding RNAs in cardiac inflammation: key drivers in the pathophysiology of heart failure. Cardiovasc Res. 2022 [doi] [PubMed]
Raso A, Dirkx E, Sampaio-Pinto V, El Azzouzi H, Cubero RJ, Sorensen DW, Ottaviani L, Olieslagers S, Huibers MM, de Weger R, Siddiqi S, Moimas S, Torrini C, Zentillin L, Braga L, Nascimento DS, da Costa Martins PA, van Berlo JH, Zacchigna S, Giacca M, De Windt LJ. A microRNA program regulates the balance between cardiomyocyte hyperplasia and hypertrophy and stimulates cardiac regeneration. Nat Commun. 2021 [doi] [PubMed]
Mesirca P, Nakao S, Nissen SD, Forte G, Anderson C, Trussell T, Li J, Cox C, Zi M, Logantha S, Yaar S, Cartensen H, Bidaud I, Stuart L, Soattin L, Morris GM, da Costa Martins PA, Cartwright EJ, Oceandy D, Mangoni ME, Jespersen T, Buhl R, Dobrzynski H, Boyett MR, D'Souza A. Intrinsic Electrical Remodeling Underlies Atrioventricular Block in Athletes. Circ Res. 2021 [doi] [PubMed]
De Majo F, Martens L, Hegenbarth JC, Rühle F, Hamczyk MR, Nevado RM, Andrés V, Hilbold E, Bär C, Thum T, de Boer M, Duncker DJ, Schroen B, Armand AS, Stoll M, De Windt LJ. Genomic instability in the naturally and prematurely aged myocardium. Proc Natl Acad Sci U S A. 2021 [doi] [PubMed]
D'Souza A, Wang Y, Anderson C, Bucchi A, Baruscotti M, Olieslagers S, Mesirca P, Johnsen AB, Mastitskaya S, Ni H, Zhang Y, Black N, Cox C, Wegner S, Bano-Otalora B, Petit C, Gill E, Logantha SJRJ, Dobrzynski H, Ashton N, Hart G, Zhang R, Zhang H, Cartwright EJ, Wisloff U, Mangoni ME, da Costa Martins PA, Piggins HD, DiFrancesco D, Boyett MR. A circadian clock in the sinus node mediates day- night rhythms in Hcn4 and heart rate. Heart Rhythm. 2021 [doi] [PubMed]
Gandhi S, Witten A, De Majo F, Gilbers M, Maessen J, Schotten U, de Windt LJ, Stoll M. Evolutionarily conserved transcriptional landscape of the heart defining the chamber specific physiology. Genomics. 2021 [doi] [PubMed]
Badimon L, Robinson EL, Jusic A, Carpusca I, deWindt LJ, Emanueli C, Ferdinandy P, Gu W, Gyöngyösi M, Hackl M, Karaduzovic-Hadziabdic K, Lustrek M, Martelli F, Nham E, Potočnjak I, Satagopam V, Schneider R, Thum T, Devaux Y. Cardiovascular RNA markers and artificial intelligence may improve COVID-19 outcome: a position paper from the EU-CardioRNA COST Action CA17129. Cardiovasc Res. 2021 [doi] [PubMed]
Sacchetto C, Mohseni Z, Colpaert RMW, Vitiello L, De Bortoli M, Vonhögen IGC, Xiao K, Poloni G, Lorenzon A, Romualdi C, Bariani R, Mazzotti E, Daliento L, Bauce B, Corrado D, Thum T, Rampazzo A, de Windt LJ, Calore M. Circulating miR-185-5p as a Potential Biomarker for Arrhythmogenic Right Ventricular Cardiomyopathy. Cells. 2021 [doi] [PubMed]
Schreurs J, Sacchetto C, Colpaert RMW, Vitiello L, Rampazzo A, Calore M. Recent Advances in CRISPR/Cas9-Based Genome Editing Tools for Cardiac Diseases. Int J Mol Sci. 2021 [doi] [PubMed]
Colpaert RMW, Calore M. Epigenetics and microRNAs in cardiovascular diseases. Genomics. 2021 [doi] [PubMed]
de Abreu RC, Ramos CV, Becher C, Lino M, Jesus C, da Costa Martins PA, Martins PAT, Moreno MJ, Fernandes H, Ferreira L. Exogenous loading of miRNAs into small extracellular vesicles. J Extracell Vesicles. 2021 [doi] [PubMed]
Sampaio-Pinto V, Silva ED, Laundos TL, da Costa Martins P, Pinto-do-Ó P, Nascimento DS. Stereological estimation of cardiomyocyte number and proliferation. Methods. 2021 [doi] [PubMed]
de Abreu RC, Fernandes H, da Costa Martins PA, Sahoo S, Emanueli C, Ferreira L. Native and bioengineered extracellular vesicles for cardiovascular therapeutics. Nat Rev Cardiol. 2020 [doi] [PubMed]
De Majo F, da Costa Martins PA. CircRNAs in the heart: bricks in Brunelleschi's Dome. Cardiovasc Res. 2020 [doi] [PubMed]
De Majo F, Hegenbarth JC, Rühle F, Bär C, Thum T, de Boer M, Duncker DJ, Schroen B, Armand AS, Stoll M, De Windt LJ. Dichotomy between the transcriptomic landscape of naturally versus accelerated aged murine hearts. Sci Rep. 2020 [doi] [PubMed]
Sacchetto C, Vitiello L, de Windt LJ, Rampazzo A, Calore M. Modeling Cardiovascular Diseases with hiPSC-Derived Cardiomyocytes in 2D and 3D Cultures. Int J Mol Sci. 2020 [doi] [PubMed]
De Bortoli M, Vio R, Basso C, Calore M, Minervini G, Angelini A, Melacini P, Vitiello L, Vazza G, Thiene G, Tosatto S, Corrado D, Iliceto S, Rampazzo A, Calore C. Novel Missense Variant in MYL2 Gene Associated With Hypertrophic Cardiomyopathy Showing High Incidence of Restrictive Physiology. Circ Genom Precis Med. 2020 [doi] [PubMed]
Vonhögen IGC, El Azzouzi H, Olieslagers S, Vasilevich A, de Boer J, Tinahones FJ, da Costa Martins PA, de Windt LJ, Murri M. MiR-337-3p Promotes Adipocyte Browning by Inhibiting TWIST1. Cells. 2020 [doi] [PubMed]
Triposkiadis F, Butler J, Abboud FM, Armstrong PW, Adamopoulos S, Atherton JJ, Backs J, Bauersachs J, Burkhoff D, Bonow RO, Chopra VK, de Boer RA, de Windt L, Hamdani N, Hasenfuss G, Heymans S, Hulot JS, Konstam M, Lee RT, Linke WA, Lunde IG, Lyon AR, Maack C, Mann DL, Mebazaa A, Mentz RJ, Nihoyannopoulos P, Papp Z, Parissis J, Pedrazzini T, Rosano G, Rouleau J, Seferovic PM, Shah AM, Starling RC, Tocchetti CG, Trochu JN, Thum T, Zannad F, Brutsaert DL, Segers VF, De Keulenaer GW. The continuous heart failure spectrum: moving beyond an ejection fraction classification. Eur Heart J. 2019 [doi] [PubMed]
Raso A, Dirkx E, Philippen LE, Fernandez-Celis A, De Majo F, Sampaio-Pinto V, Sansonetti M, Juni R, El Azzouzi H, Calore M, Bitsch N, Olieslagers S, Oerlemans MIFJ, Huibers MM, de Weger RA, Reckman YJ, Pinto YM, Zentilin L, Zacchigna S, Giacca M, da Costa Martins PA, López-Andrés N, De Windt LJ. Therapeutic Delivery of miR-148a Suppresses Ventricular Dilation in Heart Failure. Mol Ther. 2019 [doi] [PubMed]
Duygu B, Juni R, Ottaviani L, Bitsch N, Wit JBM, de Windt LJ, da Costa Martins PA. Comparison of different chemically modified inhibitors of miR-199b in vivo. Biochem Pharmacol. 2019 [doi] [PubMed]
Calore M, Lorenzon A, Vitiello L, Poloni G, Khan MAF, Beffagna G, Dazzo E, Sacchetto C, Polishchuk R, Sabatelli P, Doliana R, Carnevale D, Lembo G, Bonaldo P, De Windt L, Braghetta P, Rampazzo A. A novel murine model for arrhythmogenic cardiomyopathy points to a pathogenic role of Wnt signalling and miRNA dysregulation. Cardiovasc Res. 2019 [doi] [PubMed]
Peters MMC, Sampaio-Pinto V, da Costa Martins PA. Non-coding RNAs in endothelial cell signalling and hypoxia during cardiac regeneration. Biochim Biophys Acta Mol Cell Res. 2020 [doi] [PubMed]
Ali T, Mushtaq I, Maryam S, Farhan A, Saba K, Jan MI, Sultan A, Anees M, Duygu B, Hamera S, Tabassum S, Javed Q, da Costa Martins PA, Murtaza I. Interplay of N acetyl cysteine and melatonin in regulating oxidative stress-induced cardiac hypertrophic factors and microRNAs. Arch Biochem Biophys. 2019 [doi] [PubMed]
Sacchetto C, Sequeira V, Bertero E, Dudek J, Maack C, Calore M. Metabolic Alterations in Inherited Cardiomyopathies. J Clin Med. 2019 [doi] [PubMed]
Colpaert RMW, Calore M. MicroRNAs in Cardiac Diseases. Cells. 2019 [doi] [PubMed]
Poloni G, Calore M, Rigato I, Marras E, Minervini G, Mazzotti E, Lorenzon A, Li Mura IEA, Telatin A, Zara I, Simionati B, Perazzolo Marra M, Ponti J, Occhi G, Vitiello L, Daliento L, Thiene G, Basso C, Corrado D, Tosatto S, Bauce B, Rampazzo A, De Bortoli M. A targeted next-generation gene panel reveals a novel heterozygous nonsense variant in the TP63 gene in patients with arrhythmogenic cardiomyopathy. Heart Rhythm. 2019 [doi] [PubMed ]